Research Director

tel: +33 (0)1 44 41 25 50 - fax: +33 (0)1 44 41 25 59

Génétique Moléculaire Evolutive et Médicale
U1001 INSERM, Faculté de médecine Cochin
24 rue du Faubourg Saint Jacques, France
Short biography

Born October 12, 1959 in Split, Croatia
Croatian and French


1991-1995 PhD studies in Cellular and Molecular Genetics,
University of Paris XI, Orsay, France.
1986-1990 Graduate studies in Molecular Genetics, University of Zagreb, Croatia.
1978-1983 Undergraduate studies in Environmental Biology
Faculty of Natural Sciences, University of Zagreb, Croatia.

Tenure positions held
Since 2010 Director INSERM Unit 1001

since 2001 Research director (DR2) in the” French National Centre for Scientific Research” (CNRS) ;
INSERM U571, Faculté de Médecine Paris Descartes
1995-2001 Research scientist (CR1) in the “French National Centre for Scientific Research” (CNRS)
Institut Jacques Monod, Paris 
since 2000, CR1, INSERM U571, Faculté de médecine Paris Descartes
1986-1995 Teaching assistant at Faculty of Biotechnology and Food Technology, University of Zagreb, Croatia

Research interests

Maintenance of the genetic stability ; Modulation of mutation rates and bacterial adaptive evolution ; Host-bacteria and bacteria-bacteria interactions ; Stress responses ; Aging

Revieving activities

Biochemistry, Biochimie, Cell, Critical Reviews in Biochemistry and Molecular Biology, DNA Repair, EMBO J, Gene, Genetics, International Journal of Medical Microbiology, J of Antimicrobial Chemotherapy, J Bacteriol, J Biotechnology, J Mol.
Biol, J Mol Evol , Microbiology, MGG, Mol Microbiol, NAR, Nature Rev Microbiol, PloS Biology, PloS Computational Biology, PloS Genetics, Res Microbiol, Science, Trends in Genetics, Trends in Microbiol, PNAS USA
PloS Genetics Associated Editor  (since 2005)

Expert for evaluation of proposals

Bureau des ressources génétiques (France); French Institute of Biodiversity, Genoscope-CNS (France); French Ministry of Science; Office for international affaire of INSERM (France), Various other French Scientific Institutions and Foundations: CNRS, INRA, IFREMER, ANR, AERES, FRM.
Association for International Cancer Research  (UK); Estonian Science Foundation; Israel Science Foundation; Fund for Scientific Research Flanders (Belgium); Ministry of Science and Technology (Croatia); National Science Foundation (USA); Natural Sciences and Engineering Research Council of Canada.

Member of scientific committees

2000-2002 Member of the Scientific Council of French Institute of Biodiversity.
2003-2004 Committee of the national Council of the “French National Center for Scientific Research” (CNRS)
2006 - Member of the Scientific Council of the Medical Faculty Paris Descartes, Paris, France
2006- Member of the Scientific Council of Bioinformatics platform of the Medical Faculty Paris Descartes, Paris, France
2007- Member of the Scientific Council of the « Commission Scientifique Spécialisée - Sciences des Aliments : Microbiologie, Sécurité Alimentaire, Génie des Procédés » INRA, France


1990 Award -Krka Pharmaceuticals Prizes Foundation” (Slovenia)
2004 Award “"Pour les Sciences du Vivant” - Liliane BETTENCOURT-SCHUELLER Fondation (France)
2008 Award « Spiridon Brusina » of the Croatian Biological Society

Conferences and teaching

Every year Ivan Matic gives a dozen conferences as invited speaker at scientific meetings and in research institutions in France and worldwide.
Teaching Graduate and postgraduate studies at Paris Universities V, VI, VII and XI.

Five best publications

Matic, I., Rayssiguier, C., and Radman, M. (1995). Interspecies gene exchange in bacteria: The role of SOS and mismatch repair systems in evolution of species. Cell 80: 507-515.

Matic, I., Radman, M., Taddei, F., Picard, B., Doit, C., Binguen, E., Denamur, E. and Elion, J. (1997) Highly variable mutation rates in commensal and pathogenic Escherichia coli. Science 277: 1833-1834.

Denamur, E., Lecointre, G., Darlu, P, Acquaviva, C., Sayada, S., Sunjevaric, I., Rothstein, R., Elion, J., Taddei, F., Radman, M. and Matic, I. (2000) Evolutionary implications of the frequent horizontal transfer of mismatch repair genes. Cell 103: 711-721

Bjedov, I., Tenaillon, O., Gérard, Souza, V., Denamur, E., Radman, M., Taddei, F., and Matic, I. (2003) Stress-Induced Mutagenesis in Bacteria. Science 300:1404-1409.

Delmas, S. and Matic, I. (2006) Interplay between replication and recombination in Escherichia coli: Impact of the alternative DNA polymerases. Proc. Natl. Acad. Sci. USA 103 :4564-4569

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